Inhibition of acute experimental allergic encephalomyelitis in mice by colchicine.
نویسندگان
چکیده
منابع مشابه
Inhibition of acute experimental allergic encephalomyelitis in mice by colchicine
Colchicine was found to inhibit the clinical and histopathological manifestations of monophasic experimental allergic encephalomyelitis in mice. For inhibition of actively induced disease, inoculation of colchicine at the time of encephalitogenic challenge was found to be most effective. In adoptive transfer experiments, lymph node cells (LNC) from colchicine treated donors failed to transfer t...
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Experimental allergic encephalomyelitis (EAE) is widely regarded as a laboratory analog of multiple sclerosis (MS) . Recent evidence both in MS and EAE point to the fact that activated macrophages appear to be proximal agents of myelin destruction (1) . In view of these findings and encouraged by the preliminary results of a trial of colchicine in MS patients, we asked the question whether or n...
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Clinical, histological and electrophysiological studies were performed on rabbits with acute experimental allergic encephalomyelitis (EAE). The clinical features were similar to those previously described, with the notable exception of the new findings of areflexia, respiratory slowing and hypothermia. The histological findings were also similar to those previously reported, with inflammatory d...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1986
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.164.5.1803